[Skip to content]

Print this page

4.5 Drugs used in treatment of obesity

Orlistat Capsules (specialist obesity clinic only)


1. Orlistat is indicated for weight loss in combination with a low-calorie, low-fat diet.  NICE Technology Appraisal Guidance - No 22 states Orlistat should only be prescribed for people who have lost at least 2.5kg in weight by dietary control and increased physical activity alone in the month prior to the first prescription and meet one of the following criteria;

BMI 28kg/m2 or more in the presence of significant co-morbidities e.g type two diabetes, high blood pressure and\or high total cholesterol level.

BMI 30kg/m2 or more with no associated co-morbidities.

Treatment should not usually be continued beyond 12 months and never beyond 24 months.

2. As orlistat decreases the amount of fat absorbed from the diet, it may reduce the absorption of lipophilic drugs such as anti-retroviral HIV medicines - see MHRA Drug Safety Update.


For link to BNF section: 4.5 Drugs used in the treatment of obesity